I think it would be cool and funny if, for April Fools one year, instead of the Equestria we all know and love, we were in the LoE Human world.
It could start with the Main Menu Screen showing a human in front of "Cantermore Secondary School" instead of a pony in Ponydale, and when you open the Character Edit Menu, there is a Human with the same mane/fur colors and styles of your pony character, and you can pick out a combination of default outfits, before spawning in front of an equivalent to the CHS statue.
It could have silly mundane quests along the lines of "Find the football team's equipment" or "Help So-And-So woo their date" and stuff. There could be a school bus to take you to "Camp Evershade" or "Crystal Academy" for fun minigames and more quests respectively.
I also think it would be a good Idea that, if such a thing ever happened, the player could revisit the human world after the fact through a portal somewhere within the CSGU building.